Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
نویسندگان
چکیده
منابع مشابه
Hyperphosphorylation-Induced Tau Oligomers
In normal adult brain the microtubule associated protein (MAP) tau contains 2-3 phosphates per mol of the protein and at this level of phosphorylation it is a soluble cytosolic protein. The normal brain tau interacts with tubulin and promotes its assembly into microtubules and stabilizes these fibrils. In Alzheimer disease (AD) brain tau is three to fourfold hyperphosphorylated. The abnormally ...
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15 صفحه اولP 97: Neurodegeneration Induced by Tau protein
Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2016
ISSN: 1742-2094
DOI: 10.1186/s12974-016-0493-y